The extraordinary lifespan variation in domestic dogs provides a natural experiment for testing how intrinsic rates of ...
Traditional gene editing rewrites DNA. But a new approach, called epigenome editing, aims to treat the molecular scars we collect throughout our lives. By Emily Baumgaertner Nunn It is one of ...
The ability to precisely adjust the expression of genes inside the human body—ramping up protective ones and tamping down harmful ones—holds enormous potential for treating and preventing disease. But ...
The lack of temporal resolution in transcriptomic data during mammalian embryonic genome activation (EGA) has precluded the comprehensive understanding of the functional relationships between the ...
The signals that cells use to switch genes on have remained almost unchanged across 2 billion years of evolution, but the ones used to switch genes off vary dramatically from one branch of life to ...
Marianne Rots first started talking about epigenome editing on the conference circuit about two decades ago. If natural epigenetic marks such as DNA methylation and histone acetylation control gene ...
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Molecular clocks that can provide accurate estimates of both molecular age and lifespan across multiple mammalian species and tissue types are presented in an article published in Nature this week. An ...
A new research paper was published in Volume 18 of Aging-US on March 3, 2026, titled "P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung ...
“Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression in both TGF-β1-stimulated fibroblasts and primary IPF cells” Led by Shan Zhu — with corresponding author Yan Y ...
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