Blue-light labeling uncovers unexpected protein partners of folded DNA structures

DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).
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How Well Can Your Cells Fix Broken DNA? A Landmark Review Maps the Tools That Measure Nucleotide Excision Repair

A new critical review in Molecular Biology Reports systematically compares the biochemical, cellular, and genome-wide assays ...

The Blueprint of Life Is Not Just 4 Letters—Enzymes Have Read '8-Letter DNA'

Life on Earth writes its blueprints using only four types of letters.A, T, G, and C. If the sequence changes, the organism ...

Simulation of Life's Origin in a Giant Water Tank! Part 2

This is a side note, but......In other words, another Earth might also be destined to collide with the real Earth and merge, disappearing shortly after life begins (or while it is in the middle of ...
Science

Transposon end recognition and pairing by I-F3 CRISPR-associated transposase

To develop gene therapy tools based on CRISPR-associated transposons (CASTs), it is essential to define how transposon ends are recognized and paired during transposition. Transposon 7 (Tn7)–like ...
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Blood or skin? The starting cell may shape hidden DNA flaws in stem cell lines

Induced pluripotent stem cells have become one of the most powerful tools in modern biomedical research, offering scientists ...