Anapleurosis is the filling of the tricarboxylic acid cycle with four-carbon units. The common substrate for both anapleurosis and glucose phosphorylation in bacteria is the terminal glycolytic ...

The field of protein dynamics and allosteric regulation explores how proteins, far from being rigid entities, exhibit a wide range of motions that are integral to their function. These molecular ...

In the 50 years since the introduction of "allosteric interactions,” this concept has become one of the pillars of structural, molecular and cell biology, along with the flow of information via the ...

Enzymes in multistep metabolic pathways utilize an array of regulatory mechanisms to maintain a delicate homeostasis [K. Magnuson, S. Jackowski, C. O. Rock, J. E. Cronan, Jr, Microbiol. Rev. 57, ...

Arginine methylation on histones is a central player in epigenetics and in gene activation and repression. Protein arginine methyltransferase (PRMT) activity has been implicated in stem cell ...

The photosynthetic systems of green plants have developed a dual function of efficient light collection under low light intensity and photoprotection under intense sunshine to prevent the oxidative ...

Fluorogenic DNA aptamers produce light only in the correct structural state, enabling programmable molecular logic, ...

Yale scientists have taken a novel approach to unraveling the complex structure and regulation of enzymes: They Googled it. In a new study published online this week in the Proceedings of the National ...

Proteins known as G protein-coupled receptors, or GPCRs for short, detect and respond to hormones and other signaling molecules found outside cells. A signaling molecule activates a GPCR by binding to ...

Researchers have taken another step towards realizing a new class of PCR enzyme mimics, opening the door for the development of highly sensitive chemical detection systems that go beyond nucleic acid ...